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We persistently found that the inhabitants of dividing astrocytes was significantly smaller on the side by which N-CAM or one of the N-CAM-related molecules was infused than on the alternative side. The inhibition was best in the cortical lesion websites (approximately 50%) and was less pronounced within the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical websites infused with N-CAM continued to exhibit a considerably smaller inhabitants of dividing astrocytes than the sites on the alternative aspect.

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  • Hoffman S, Edelman GM. The mechanism of binding of neural cell adhesion molecules.
  • Miyake T, Hattori T, Fukuda M, Kitamura T. Reactions of S-100-positive glia after damage of mouse cerebral cortex.

Janeczko K. The proliferative response of astrocytes to harm in neonatal rat mind. Janeczko K. The proliferative response of S-100 protein-positive glial cells to harm within the neonatal rat mind. Ssexs O, Edelman GM, Crossin KL. The neural cell adhesion molecule (N-CAM) inhibits proliferation in primary cultures of rat astrocytes. The California Condor Recovery Program is a multi-entity effort, led by the U.S.

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When N-CAM and primary fibroblast growth issue, which is known to stimulate astrocyte division in vitro, have been coinfused into cortical lesion websites, astrocyte proliferation was nonetheless inhibited. These results recommend the speculation that, by reducing glial proliferation, N-CAM or its peptides could help create an environment that is extra suitable for neuronal regeneration. As of 2014, there have been greater than 230 individuals within the wild in California, Arizona, and Baja California. The number has been rising steadily every year, as captive-bred birds are launched and wild pairs fledge young from their very own nests.

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